Supporters of the Act said the House also is likely to give quick approval to the bill, sending it to President Bush for his signature.
A similar bill passed the House by a 420-3 vote a year ago. The White House, at the time, indicated its support for the legislation.
A last-minute compromise was reached on the bill with Sen. Tom Coburn, (R., Okla.), who had been blocking Senate action on the bill, changing some language to ensure there is a "firewall" between the part dealing with health plans and the section regarding employment so as to discourage inappropriate claims.
Bill supporters said that nearly 32 percent of women offered a genetic test for breast cancer risk by the National Institutes of Health declined because of concerns about health insurance discrimination. They add that "Like discrimination based on race and gender, genetic discrimination is based on the unchangeable and -- because the information must be sought out by the offender -- is equally offensive."
Supporters say the bill will "unlock the extraordinary potential of this new era of the life sciences."